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Proc Natl Acad Sci U S A. 2013 May 7;110(19):7886-91. doi: 10.1073/pnas.1305219110. Epub 2013 Apr 22.

Origin of intrinsic irregular firing in cortical interneurons.

Author information

1
Computational Neurobiology Laboratory and Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Cortical spike trains are highly irregular both during ongoing, spontaneous activity and when driven at high firing rates. There is uncertainty about the source of this irregularity, ranging from intrinsic noise sources in neurons to collective effects in large-scale cortical networks. Cortical interneurons display highly irregular spike times (coefficient of variation of the interspike intervals >1) in response to dc-current injection in vitro. This is in marked contrast to cortical pyramidal cells, which spike highly irregularly in vivo, but regularly in vitro. We show with in vitro recordings and computational models that this is due to the fast activation kinetics of interneuronal K(+) currents. This explanation holds over a wide parameter range and with Gaussian white, power-law, and Ornstein-Uhlenbeck noise. The intrinsically irregular spiking of interneurons could contribute to the irregularity of the cortical network.

KEYWORDS:

bistability; cortex; fluctuations; inhibitory interneuron; neural noise

PMID:
23610409
PMCID:
PMC3651468
DOI:
10.1073/pnas.1305219110
[Indexed for MEDLINE]
Free PMC Article
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