Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2013 May;14(5):307-14. doi: 10.1038/nrm3568.

Sticking together the Crumbs - an unexpected function for an old friend.

Author information

1
Cancer Research UK, London Research Institute, 44 Lincolns Inn Fields, London, WC2A 3LY, UK. barry.thompson@cancer.org.uk

Abstract

Cell polarity and cell-cell junctions have pivotal roles in organizing cells into tissues and in mediating cell-cell communication. The transmembrane protein Crumbs has a well-established role in the maintenance of epithelial polarity, and it can also regulate signalling via the Notch and Hippo pathways to influence tissue growth. The functions of Crumbs in epithelial polarity and Hippo-mediated growth depend on its short intracellular domain. Recent evidence now points to a conserved and fundamental role for the extracellular domain of Crumbs in mediating homophilic Crumbs-Crumbs interactions at cell-cell junctions.

PMID:
23609509
DOI:
10.1038/nrm3568
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center