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J Surg Oncol. 2013 Jun;107(7):767-71. doi: 10.1002/jso.23312. Epub 2013 Apr 23.

Serum miR-19a expression correlates with worse prognosis of patients with non-small cell lung cancer.

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1
Department of Respiratory Medicine, Affiliated Hospital of Putian University, Putian, Fujian, China.

Abstract

OBJECTIVES:

The aim of this study was to investigate the expression levels of miR-19a in non-small cell lung cancer (NSCLC) tissue and serum, and to clarify the relationships of serum miR-19a expression with clinical factors and prognosis of NSCLC patients.

METHODS:

Expression levels of miR-19a in 25 paired NSCLC, paracancerous tissues and serum, and sera from 103 controls and 201 NSCLC patients were respectively detected using real-time quantitative PCR.

RESULTS:

Compared with the paracancerous tissue, miR-19a was overexpressed in NSCLC tissue (P = 0.006), and there was a strong correlation between expression levels of miR-19 in 25 paired sera and tissues (P = 0.001). Serum miR-19a expression in NSCLC patients was significantly upregulated compared with those in healthy individuals (P = 0.001). High serum miR-19a expression was significantly correlated with TNM stage and lymph node metastasis (P = 0.004 and 0.017, respectively). Survival analysis revealed that overall survival rate of patients with high serum miR-19a expression was significantly worse than those of patients with low serum miR-19a expression (hazard ratio = 1.438, 95% confidence interval 1.007-2.052, P = 0.046).

CONCLUSION:

High serum miR-19a expression may be an independent poor prognostic factor for survival in NSCLC patients.

PMID:
23609137
DOI:
10.1002/jso.23312
[Indexed for MEDLINE]

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