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J Theor Biol. 2013 Sep 7;332:267-90. doi: 10.1016/j.jtbi.2013.03.024. Epub 2013 Apr 19.

Towards multiscale modeling of influenza infection.

Author information

1
Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. lmurillo@lanl.gov

Abstract

Aided by recent advances in computational power, algorithms, and higher fidelity data, increasingly detailed theoretical models of infection with influenza A virus are being developed. We review single scale models as they describe influenza infection from intracellular to global scales, and, in particular, we consider those models that capture details specific to influenza and can be used to link different scales. We discuss the few multiscale models of influenza infection that have been developed in this emerging field. In addition to discussing modeling approaches, we also survey biological data on influenza infection and transmission that is relevant for constructing influenza infection models. We envision that, in the future, multiscale models that capitalize on technical advances in experimental biology and high performance computing could be used to describe the large spatial scale epidemiology of influenza infection, evolution of the virus, and transmission between hosts more accurately.

KEYWORDS:

Epidemiological; Influenza A virus model; Metapopulation; Networks; Viral kinetics

PMID:
23608630
PMCID:
PMC3758892
DOI:
10.1016/j.jtbi.2013.03.024
[Indexed for MEDLINE]
Free PMC Article
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