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Trends Immunol. 2013 Oct;34(10):482-6. doi: 10.1016/j.it.2013.03.001. Epub 2013 Apr 20.

The physiological role of DC-SIGN: a tale of mice and men.

Author information

1
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, 1081BT, The Netherlands.

Abstract

The innate immune receptor DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin) was discovered over a decade ago and was initially identified as a pattern recognition receptor. In addition to its ability to recognize a broad range of pathogen-derived ligands and self-glycoproteins, DC-SIGN also mediates intercellular adhesion, as well as antigen uptake and signaling, which is a functional hallmark of dendritic cells (DCs). Most research on DC-SIGN has relied on in vitro studies. The in vivo function of DC-SIGN is difficult to address, in part because there are eight genetic homologs in mice with no clear DC-SIGN ortholog. Here, we summarize the functions attributed to DC-SIGN based on in vitro data and discuss the limitations of available mouse models to uncover the physiological role of this receptor in vivo.

KEYWORDS:

DC-SIGN; animal models; antigen presentation; pattern recognition receptors

PMID:
23608151
DOI:
10.1016/j.it.2013.03.001
[Indexed for MEDLINE]

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