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Neuropsychologia. 2013 Oct;51(12):2360-70. doi: 10.1016/j.neuropsychologia.2013.04.004. Epub 2013 Apr 19.

Neural correlates of retrieval-based memory enhancement: an fMRI study of the testing effect.

Author information

1
Department of Psychology & Neuroscience, Duke University, Box 90086, 417 Chapel Drive, Duke University, Durham, NC 27708. United States; Center for Cognitive Neuroscience, Duke University, Box 90999, B203 Levine Science Research Center, Durham, NC 27708. United States. Electronic address: erik.wing@duke.edu.

Abstract

Restudying material is a common method for learning new information, but not necessarily an effective one. Research on the testing effect shows that practice involving retrieval from memory can facilitate later memory in contrast to passive restudy. Despite extensive behavioral work, the brain processes that make retrieval an effective learning strategy remain unclear. In the present experiment, we explored how initially retrieving items affected memory a day later as compared to a condition involving traditional restudy. In contrast to restudy, initial testing that contributed to future memory success was associated with engagement of several regions including the anterior hippocampus, lateral temporal cortices, and medial prefrontal cortex (PFC). Additionally, testing enhanced hippocampal connectivity with ventrolateral PFC and midline regions. These findings indicate that the testing effect may be contingent on processes that are typically thought to support memory success at encoding (e.g. relational binding, selection and elaboration of semantically-related information) in addition to those more often associated with retrieval (e.g. memory search).

KEYWORDS:

Episodic memory; Hippocampus; Medial PFC; Retrieval practice; Testing effect; fMRI

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