Format

Send to

Choose Destination
Mult Scler Int. 2013;2013:671730. doi: 10.1155/2013/671730. Epub 2013 Mar 31.

DTI Measurements in Multiple Sclerosis: Evaluation of Brain Damage and Clinical Implications.

Author information

1
Department of Neurology and Psychiatry, Sapienza University, Viale dell'Università 30, 00185 Rome, Italy.

Abstract

Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded noteworthy results. DTI abnormalities, which are already detectable in patients with clinically isolated syndrome (CIS), become more pronounced as disease duration and neurological impairment increase. The assessment of the microstructural alterations of white and grey matter in MS may shed light on mechanisms responsible for irreversible disability accumulation. In this paper, we examine the DTI analysis methods, the results obtained in the various tissues of the central nervous system, and correlations with clinical features and other MRI parameters. The adoption of DTI metrics to assess the outcome of prognostic measures may represent an extremely important step forward in the MS research field.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center