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Infect Dis Obstet Gynecol. 2013;2013:525878. doi: 10.1155/2013/525878. Epub 2013 Mar 28.

Duration of intrapartum antibiotics for group B streptococcus on the diagnosis of clinical neonatal sepsis.

Author information

1
Department of Obstetrics & Gynecology, Kelsey-Seybold West Clinic, 1111 Augusta Drive, Houston, TX 77057, USA. mark.turrentine@kelsey-seybold.com

Abstract

BACKGROUND:

Infants born to mothers who are colonized with group B streptococcus (GBS) but received <4 hours of intrapartum antibiotic prophylaxis (IAP) are at-risk for presenting later with sepsis. We assessed if <4 hours of maternal IAP for GBS are associated with an increased incidence of clinical neonatal sepsis.

MATERIALS AND METHODS:

A retrospective cohort study of women-infant dyads undergoing IAP for GBS at ≥37-week gestation who presented in labor from January 1, 2003 through December 31, 2007 was performed. Infants diagnosed with clinical sepsis by the duration of maternal IAP received (< or ≥4-hours duration) were determined.

RESULTS:

More infants whose mothers received <4 hours of IAP were diagnosed with clinical sepsis, 13 of 1,149 (1.1%) versus 15 of 3,633 (0.4%), P = .03. Multivariate logistic regression analysis showed that treatment with ≥4 hours of IAP reduced the risk of infants being diagnosed with clinical sepsis by 65%, adjusted relative risk 0.35, CI 0.16-0.79, and P = .01.

CONCLUSION:

The rate of neonatal clinical sepsis is increased in newborns of GBS colonized mothers who receive <4 hours compared to ≥4 hours of IAP.

PMID:
23606801
PMCID:
PMC3625608
DOI:
10.1155/2013/525878
[Indexed for MEDLINE]
Free PMC Article
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