Format

Send to

Choose Destination
See comment in PubMed Commons below
Mediators Inflamm. 2013;2013:654963. doi: 10.1155/2013/654963. Epub 2013 Mar 28.

Inflammasome in intestinal inflammation and cancer.

Author information

1
Biofunctionality Unit, ZIEL Research Center for Nutrition and Food Sciences, Technical University of Munich, 85354 Freising-Weihenstephan, Germany.

Abstract

The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β , and IL-18, with subsequent activation of the innate immune response. In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens.

PMID:
23606794
PMCID:
PMC3625567
DOI:
10.1155/2013/654963
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center