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Chem Asian J. 2013 Aug;8(8):1634-44. doi: 10.1002/asia.201300262. Epub 2013 Apr 18.

RAFT polymerization and some of its applications.

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Materials Science and Engineering, CSIRO, Bayview Ave, Clayton, Victoria 3168, Australia.


Reversible addition-fragmentation chain transfer (RAFT) is one of the most robust and versatile methods for controlling radical polymerization. With appropriate selection of the RAFT agent for the monomers and reaction conditions, it is applicable to the majority of monomers subject to radical polymerization. The process can be used in the synthesis of well-defined homo-, gradient, diblock, triblock, and star polymers and more complex architectures, which include microgels and polymer brushes. In this Focus Review we describe how the development of RAFT and RAFT application has been facilitated by the adoption of continuous flow techniques using tubular reactors and through the use of high-throughput methodology. Applications described include the use of RAFT in the preparation of polymers for optoelectronics, block copolymer therapeutics, and star polymer rheology control agents.


RAFT; mechanism; polymerization; radicals; synthesis design


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