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NMR Biomed. 2013 Jul;26(7):860-71. doi: 10.1002/nbm.2948. Epub 2013 Apr 22.

In vivo MRI cell tracking using perfluorocarbon probes and fluorine-19 detection.

Author information

1
Department of Biological Sciences and Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA 15213, USA. eta@cmu.edu

Abstract

This article presents a brief review of preclinical in vivo cell-tracking methods and applications using perfluorocarbon (PFC) probes and fluorine-19 ((19) F) MRI detection. Detection of the (19) F signal offers high cell specificity and quantification ability in spin density-weighted MR images. We discuss the compositions of matter, methods and applications of PFC-based cell tracking using ex vivo and in situ PFC labeling in preclinical studies of inflammation and cellular therapeutics. We also address the potential applicability of (19) F cell tracking to clinical trials.

PMID:
23606473
PMCID:
PMC3893103
DOI:
10.1002/nbm.2948
[Indexed for MEDLINE]
Free PMC Article

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