Mid-term evaluation of the new Glaukos iStent with phacoemulsification in coexistent open-angle glaucoma or ocular hypertension and cataract

Br J Ophthalmol. 2013 Oct;97(10):1250-5. doi: 10.1136/bjophthalmol-2012-302394. Epub 2013 Apr 20.

Abstract

Aims: To evaluate the mid-term efficacy and safety of the GTS-400-iStent combined with phacoemulsification in patients with cataract and open-angle glaucoma (OAG) or ocular hypertension (OHT).

Methods: Prospective, non-comparative, uncontrolled, interventional case series study. Subjects underwent phacoemulsification and two GTS-400 implantation. Efficacy outcomes: intraocular pressure (IOP) and antiglaucoma medications. Safety outcomes: complications, best-corrected visual acuity and endothelial cell count (ECC). Follow-up was 1 year.

Results: 20 patients were enrolled (mean age: 75.1 ± 8.6 years). Mean medicated baseline IOP was 19.95 ± 3.71 mm Hg and 26 ± 3.11 mm Hg without medication. Mean final IOP was 16.75 ± 2.24, determining a final IOP decrease of 35.68% (9.42 ± 3 mm Hg; p<0.001), from baseline washout IOP. Mean number of medications fell from 1.3 ± 0.66 to 0.3 ± 0.57 (P<0.001). 75% of patients were off medications at one year. Mean ECC decreased from 2289.64 ± 393.5 cells/mm(2) to 1986.95 ± 520.58 cells/mm(2).

Conclusions: Combined cataract surgery with implantation of GTS-400-iStent seems to be an effective and safe procedure.

Keywords: Aqueous humour; Glaucoma; Treatment Surgery.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / administration & dosage
  • Cataract / complications*
  • Female
  • Follow-Up Studies
  • Glaucoma Drainage Implants*
  • Glaucoma, Open-Angle / complications
  • Glaucoma, Open-Angle / physiopathology
  • Glaucoma, Open-Angle / surgery*
  • Humans
  • Intraocular Pressure / physiology
  • Male
  • Middle Aged
  • Ocular Hypertension / complications
  • Ocular Hypertension / physiopathology
  • Ocular Hypertension / surgery*
  • Phacoemulsification*
  • Prospective Studies
  • Visual Acuity / physiology

Substances

  • Antihypertensive Agents