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Clin Nucl Med. 2013 Nov;38(11):e426-8. doi: 10.1097/RLU.0b013e3182815cbf.

SPECT myocardial perfusion in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

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From the *Department of Nuclear Medicine, †Neurology, ‡Internal Medicine, Cardiology Division, §Physical Medicine and Rehabilitation, and ¶Radiology, Wonkwang University School of Medicine and Institute of Wonkwang Medical Science, Iksan, Republic of Korea.


Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary small vessel disease. Although the symptoms are exclusively neurological, arteriopathy is generalized. We performed cardiac evaluation using myocardial perfusion single photon emission computed tomography (SPECT), dual-source 128-channel multidetector computed tomography (MDCT) angiogram, echocardiogram, and electrocardiogram (ECG) in a 46-year-old woman with CADASIL. No abnormal findings were observed on MDCT angiogram, echocardiogram, or ECG. However, SPECT demonstrated reversible perfusion defects in the left anterior descending artery territory. We suggest that myocardial perfusion SPECT is a valuable tool to identify risk from cardiovascular accident in CADASIL patients.

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