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Contact Dermatitis. 2013 May;68(5):286-92. doi: 10.1111/cod.12053.

Unexpected loss of contact allergy to aluminium induced by vaccine.

Author information

1
Department of Dermatology and Venereology, Sahlgrenska University Hospital, S-413 45 Gothenburg, Sweden. anette.gente.lidholm@vgregion.se

Abstract

BACKGROUND:

In studies in Gothenburg, Sweden, in the 1990s of an aluminium hydroxide-adsorbed pertussis toxoid vaccine, 745 of ~76 000 vaccinated children developed long-lasting itchy subcutaneous nodules at the vaccination site. Of 495 children with itchy nodules patch tested for aluminium allergy, 376 (76%) were positive.

OBJECTIVES:

To study the prognosis of the vaccine-induced aluminium allergy.

PATIENTS AND METHODS:

Two hundred and forty-one children with demonstrated aluminium allergy in the previous study were patch tested again 5-9 years after the initial test, with the same procedure as used previously.

RESULTS:

Contact allergy to aluminium was no longer demonstrable in 186 of the retested 241 children (77%). A negative test result was more common in children who no longer had itching at the vaccination site; it was also related to the age of the child, the time after the first aluminium-adsorbed vaccine dose, and the strength of the reaction in the first test.

CONCLUSIONS:

Patch test reactivity to aluminium seems to disappear or weaken with time.

PMID:
23601064
PMCID:
PMC3734622
DOI:
10.1111/cod.12053
[Indexed for MEDLINE]
Free PMC Article

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