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Thorax. 2013 Nov;68(11):1079-80. doi: 10.1136/thoraxjnl-2012-202974. Epub 2013 Apr 18.

Tuberculosis during TNF-α inhibitor therapy, despite screening.

Author information

1
Department of Pulmonology and Tuberculosis, Diakonessenhuis Utrecht, , Utrecht, The Netherlands.

Abstract

As part of a prospective study on the safety of TNF-α inhibitor therapy after screening for and treatment of latent tuberculosis infection (LTBI), we report two patients who developed active tuberculosis (TB) infection during TNF-α inhibitor therapy, despite negative screening for LTBI. The clinical history is suggestive of a primary infection acquired during travelling to TB-endemic countries. In this lesson of the month we would like to highlight the risk of travelling to TB-endemic areas in patients treated with TNF-α inhibitor therapy. Screening for latent tuberculosis infection is not enough to prevent tuberculosis in patients treated with TNF-α inhibitor therapy.

KEYWORDS:

Immunodeficiency; Infection Control; Respiratory Infection; Tuberculosis

PMID:
23598710
DOI:
10.1136/thoraxjnl-2012-202974
[Indexed for MEDLINE]

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