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Clin Pharmacol Ther. 2013 May;93(5):384-5. doi: 10.1038/clpt.2013.7.

Clinical implementation of pharmacogenetics: more than one gene at a time.

Author information

1
Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, Florida, USA.

Abstract

Tricyclic antidepressant (TCA) clinical pharmacogenetic implementation guidelines for CYP2D6 and CYP2C19 genotypes highlight the importance of both genes. However, studies of the combined impact of the two genes are sparse, limiting the ability to make strong recommendations based on both genes. The warfarin pharmacogenetics literature highlights the strength of a multigenic approach for discovery and clinical implementation. For optimal impact and interpretation, investigators are encouraged to conduct studies in the context of previously well-defined pharmacogenetics markers.

PMID:
23598455
PMCID:
PMC3716458
DOI:
10.1038/clpt.2013.7
[Indexed for MEDLINE]
Free PMC Article

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