Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Protoc. 2013 May;8(5):949-57. doi: 10.1038/nprot.2013.050. Epub 2013 Apr 18.

Studying task-related activity of individual neurons in the human brain.

Author information

1
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA. shaun.patel@me.com

Abstract

Single-neuronal studies remain the gold standard for studying brain function. Here we describe a protocol for studying task-related single-neuronal activity in human subjects during neurosurgical procedures involving microelectrode recordings. This protocol has two phases: a preoperative phase and an intraoperative phase. During the preoperative phase, we discuss informed consent, equipment setup and behavioral testing. During the intraoperative phase, we discuss the procedure for microelectrode recordings. Because patients are often awake during these procedures, this protocol can be performed in conjunction with behavioral tasks for studying a variety of cognitive functions. We describe the protocol in detail and provide two examples of expected results. In addition, we discuss the potential difficulties and pitfalls related to intraoperative studies. This protocol takes ∼1.5 h to complete.

PMID:
23598445
DOI:
10.1038/nprot.2013.050
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center