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Nat Immunol. 2013 May;14(5):428-36. doi: 10.1038/ni.2588. Epub 2013 Apr 18.

Understanding immunosenescence to improve responses to vaccines.

Author information

1
The Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA. jgoronzy@stanford.edu

Abstract

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly because of the adaptive immune system's inability to generate protective immunity. The age-dependent decrease in immunological competence, often referred to as 'immunosenescence', results from the progressive deterioration of innate and adaptive immune responses. Most insights into mechanisms of immunological aging have been derived from studies of mouse models. In this Review, we explore how well such models are applicable to understanding the aging process throughout the 80-100 years of human life and discuss recent advances in identifying and characterizing the mechanisms that underlie age-associated defective adaptive immunity in humans.

PMID:
23598398
PMCID:
PMC4183346
DOI:
10.1038/ni.2588
[Indexed for MEDLINE]
Free PMC Article

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