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Cancer Cell. 2013 Apr 15;23(4):429-31. doi: 10.1016/j.ccr.2013.04.004.

It's the peptide-MHC affinity, stupid.

Author information

1
Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.

Abstract

Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy.

PMID:
23597560
DOI:
10.1016/j.ccr.2013.04.004
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