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Dev Cell. 2013 Apr 15;25(1):5-13. doi: 10.1016/j.devcel.2013.03.016.

Gene regulatory networks governing pancreas development.

Author information

1
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.

Abstract

Elucidation of cellular and gene regulatory networks (GRNs) governing organ development will accelerate progress toward tissue replacement. Here, we have compiled reference GRNs underlying pancreas development from data mining that integrates multiple approaches, including mutant analysis, lineage tracing, cell purification, gene expression and enhancer analysis, and biochemical studies of gene regulation. Using established computational tools, we integrated and represented these networks in frameworks that should enhance understanding of the surging output of genomic-scale genetic and epigenetic studies of pancreas development and diseases such as diabetes and pancreatic cancer. We envision similar approaches would be useful for understanding the development of other organs.

PMID:
23597482
PMCID:
PMC3645877
DOI:
10.1016/j.devcel.2013.03.016
[Indexed for MEDLINE]
Free PMC Article

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