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Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(1):49-52.

[Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound].

[Article in Chinese]

Author information

1
Southwest University for Nationalities, Chengdu 610041, China. 171949699@qq.com

Abstract

OBJECTIVE:

To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro.

METHOD:

The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets.

RESULT:

Drug release profiles in vitro were affected obviously by membrane thickness, penetrating agents and porogen.

CONCLUSION:

Membrane controlled tablets of puerarin inclusion compound were prepared according to the optimal formulation with zero-order kinetics.

PMID:
23596875
[Indexed for MEDLINE]
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