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Wei Sheng Yan Jiu. 2013 Jan;42(1):107-9, 113.

[Effects of angelica keiskei chalcone on expression of glucose transporter proteins in liver and skeletal muscle cells of type 2 diabetic rats].

[Article in Chinese]

Author information

1
Department of Public Health, Medical Collage of Qingdao University, Qingdao 266021, China. zhaoyang5256@126.com

Abstract

OBJECTIVE:

To investigate the effect of angelica keiskei chalcone (AC) on the expression of glucose transporter2 (Glut2) in liver and glucose transporter 4 (Glut4) in skeletal muscle cells of rats with type2 diabetes.

METHODS:

Made type2 diabetic rat models and divided into high, middle, low dose groups and diabetic control group randomly which were given chalcone 30, 10, 5 and 0 mg/kg BW respectively. Four groups were fed with the diet containing high fat. After four weeks, fasting blood glucose was determined by glucose oxidase method. Insulin was assessed by radio-immunity method. The expression levels of Glut2 in liver and Glut4 in skeletal muscle cells were analyzed by immunohistochemistry method.

RESULTS:

After analyzed by Image-Pro Plus on immunohistochemistry pictures, the expression levels of Glut2 in liver and Glut4 in skeletal muscle cells in high group were (0.036 +/- 0.0030) and (0.063 +/- 0.0139), which were significantly higher than the model control group (P < 0.05). The levels of fasting blood glucose and insulin in high dose group were (12.3 +/- 1.64) mmol/L and (25.65 +/- 3.34) microIU/ml, significantly lower than those of the model control group (P < 0.05).

CONCLUSION:

Angelica keiskei chalcone may increase the expression levels of Glut2 in liver and Glut4 in skeletal muscle cells, decrease fasting blood glucose and insulin of type 2 diabetic rats and improve their insulin resistance condition.

PMID:
23596719
[Indexed for MEDLINE]
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