[Fe]-hydrogenase and models that contain iron-acyl ligation

Katherine M Schultz; Dafa Chen; Xile Hu

doi:10.1002/asia.201300232

[Fe]-hydrogenase and models that contain iron-acyl ligation

Chem Asian J. 2013 Jun;8(6):1068-75. doi: 10.1002/asia.201300232. Epub 2013 Apr 17.

Authors

Katherine M Schultz¹, Dafa Chen, Xile Hu

Affiliation

¹ Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC-LSCI, BCH 3305, Lausanne, CH 1015, Switzerland.

PMID: 23596151
DOI: 10.1002/asia.201300232

Abstract

[Fe]-hydrogenase is a newly characterized type of hydrogenase. This enzyme heterolytically splits hydrogen in the presence of a natural substrate. The active site of the enzyme contains a mono-iron complex with intriguing iron-acyl ligation. Several groups have recently developed iron-acyl complexes as synthetic models of [Fe]-hydrogenase. This Focus Review summarizes the studies of this enzyme and its model compounds, with an emphasis on our own research in this area.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acylation
Catalytic Domain
Hydrogenase / chemistry*
Iron / chemistry*
Iron-Sulfur Proteins / chemistry*
Ligands
Models, Molecular*
X-Ray Absorption Spectroscopy

Substances

Iron-Sulfur Proteins
Ligands
Iron
iron hydrogenase
Hydrogenase