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Neurology. 2013 May 14;80(20):1826-33. doi: 10.1212/WNL.0b013e3182929f38. Epub 2013 Apr 17.

Traumatic brain injury impairs small-world topology.

Author information

1
Computational, Cognitive and Clinical Neuroimaging Laboratory, The Division of Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK.

Abstract

OBJECTIVE:

We test the hypothesis that brain networks associated with cognitive function shift away from a "small-world" organization following traumatic brain injury (TBI).

METHODS:

We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging.

RESULTS:

Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics.

CONCLUSIONS:

We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI.

PMID:
23596068
PMCID:
PMC3908350
DOI:
10.1212/WNL.0b013e3182929f38
[Indexed for MEDLINE]
Free PMC Article
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