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Ann Neurol. 2013 Jun;73(6):751-61. doi: 10.1002/ana.23797. Epub 2013 Apr 17.

In vivo assessment of amyloid-β deposition in nondemented very elderly subjects.

Author information

1
Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA. mathisca@upmc.edu

Abstract

OBJECTIVE:

This study examined amyloid-β (Aβ) deposition in 190 nondemented subjects aged ≥82 years to determine the proportion of Aβ-positive scans and associations with cognition, apolipoprotein E (APOE) status, brain volume, and Ginkgo biloba (Gb) treatment.

METHODS:

Subjects who agreed to participate had a brain magnetic resonance imaging and positron emission tomography scan with (11) C-labeled Pittsburgh compound B (PiB) following completion of a Gb treatment clinical trial. The youngest subject in this imaging study was 82 years, and the mean age of the subjects was 85.5 years at the time of the scans; 152 (80%) were cognitively normal, and 38 (20%) were diagnosed with mild cognitive impairment (MCI) at the time of the PiB study.

RESULTS:

A high proportion of the cognitively normal subjects (51%) and MCI subjects (68%) were PiB-positive. The APOE*4 allele was more prevalent in PiB-positive than in PiB-negative subjects (30% vs 6%). Measures of memory, language, and attentional functions were worse in PiB-positive than in PiB-negative subjects, when both normal and MCI cases were analyzed together; however, no significant associations were observed within either normal or MCI subject groups alone. There was no relationship between Gb treatment and Aβ deposition as determined by PiB.

INTERPRETATION:

The data revealed a 55% prevalence of PiB positivity in nondemented subjects age >80 years and 85% PiB positivity in the APOE*4 nondemented elderly subjects. The findings also showed that long-term exposure to Gb did not affect the prevalence of cerebral Aβ deposition.

PMID:
23596051
PMCID:
PMC3725727
DOI:
10.1002/ana.23797
[Indexed for MEDLINE]
Free PMC Article

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