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Chirurg. 2013 Jun;84(6):492-6. doi: 10.1007/s00104-012-2433-4.

[Intraoperative chemotherapy after radical pleurectomy or extrapleural pneumonectomy].

[Article in German]

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Abteilung f├╝r Thoraxchirurgie, Universit├Ątsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Deutschland.


Trimodality treatment including induction and/or adjuvant chemotherapy, surgical resection and in some cases radiotherapy offers a curative intention in selected patients with pleural malignancies (malignant pleural mesothelioma, thymoma with pleural spread). Nevertheless, locoregional tumor recurrence mainly limits the outcome and the quality of life. A few years ago an additional intraoperative chemotherapy perfusion was developed in order to improve local tumor control and prognosis after surgical resection in a multimodality treatment setting. Cytoreductive surgery with the purpose of a macroscopic complete resection could be achieved by radical pleurectomy or extrapleural pneumonectomy. The concept, techniques and perioperative management of this additional treatment option are presented along with a detailed review of the recent literature.

[Indexed for MEDLINE]

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