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Clin Infect Dis. 2013 Aug;57(4):564-72. doi: 10.1093/cid/cit247. Epub 2013 Apr 17.

Matrix-assisted laser desorption ionization-time of flight mass spectrometry in clinical microbiology.

Author information

1
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology and Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA. patel.robin@mayo.edu

Abstract

Despite widespread application of nucleic acid diagnostics, cultures remain integral in modern laboratories. Because cultures detect a large number of organism types, it is unlikely that they will disappear from clinical practice in the near future. Their downside is slow turn-around time, impacted by time to growth and identification of that growth. The latter is expedited using a new proteomic technology, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).

KEYWORDS:

MALDI-TOF; bacteria; fungi; mass spectrometry; matrix-assisted laser desorption ionization-time of flight

PMID:
23595835
DOI:
10.1093/cid/cit247
[Indexed for MEDLINE]

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