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Curr Protoc Hum Genet. 2013;Chapter 1:Unit1.24. doi: 10.1002/0471142905.hg0124s77.

Methods for meta-analysis of genetic data.

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1
Boston University School of Public Health, Boston, MA, USA.

Abstract

Modern genetic association studies, using genome-wide genotype data, are often underpowered. Meta-analyses of multiple studies performing genome-wide genotyping improve power and have led to the identification of thousands of genotype-trait associations. This unit provides an overview of the key concepts required for genetic meta-analyses, and presents strategic approaches and key decisions that must be made in the process of performing genome-wide association study (GWAS) meta-analyses. The commentary discusses the interpretation of GWAS meta-analysis results, complications, and some of the possible next steps once a GWAS meta-analysis has successfully identified regions associated with a trait.

PMID:
23595597
DOI:
10.1002/0471142905.hg0124s77
[Indexed for MEDLINE]
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