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Chem Soc Rev. 2013 May 21;42(10):4476-91. doi: 10.1039/c3cs60097a. Epub 2013 Apr 18.

Glycopolymer probes of signal transduction.

Author information

1
Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, WI 53706, USA. kiessling@chem.wisc.edu

Abstract

Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the underlying molecular mechanisms by which glycans manifest their function requires access to glycan derivatives that vary systematically. To this end, glycopolymers (polymers bearing pendant carbohydrates) have emerged as valuable glycan analogs. Because glycopolymers can readily be synthesized, their overall shape can be varied, and they can be altered systematically to dissect the structural features that underpin their activities. This review provides examples in which glycopolymers have been used to effect carbohydrate-mediated signal transduction. Our objective is to illustrate how these powerful tools can reveal the molecular mechanisms that underlie carbohydrate-mediated signal transduction.

PMID:
23595539
PMCID:
PMC3808984
DOI:
10.1039/c3cs60097a
[Indexed for MEDLINE]
Free PMC Article

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