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Neurosci Lett. 1990 May 4;112(2-3):239-45.

Synchronization of epileptiform bursts induced by 4-aminopyridine in the in vitro hippocampal slice preparation.

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Department of Physiology and Biophysics, St. Mary's Hospital Medical School, Imperial College, University of London, U.K.


Neuronal activity in hippocampal slices can be synchronized by drugs which either block synaptic inhibition (e.g. bicuculline methiodide) or do not (e.g. 4-aminopyridine). Here we compare these two drugs to assess the role of inhibition on the recruitment of neurones into synchronous epileptiform bursts. With 4-aminopyridine we recorded an acceleration of neuronal activity, and in most cells a slow depolarization (mean 6.8 mV), during the ca. 100 ms preceding the population burst. With bicuculline these changes occurred ca. 10 ms before the population bursts, and depolarizations reached a mean of 2.5 mV. We propose that bicuculline-sensitive synaptic inhibition retards the recruitment of neurones into epileptiform synchronous bursts.

[Indexed for MEDLINE]

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