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Euro Surveill. 2013 Apr 4;18(14):20441.

Specific serology for emerging human coronaviruses by protein microarray.

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Centre for Infectious Disease Control, Division Virology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.


We present a serological assay for the specific detection of IgM and IgG antibodies against the emerging human coronavirus hCoV-EMC and the SARS-CoV based on protein microarray technology. The assay uses the S1 receptor-binding subunit of the spike protein of hCoV-EMC and SARS-CoV as antigens. The assay has been validated extensively using putative cross-reacting sera of patient cohorts exposed to the four common hCoVs and sera from convalescent patients infected with hCoV-EMC or SARS-CoV.

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