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PLoS One. 2013 Apr 8;8(4):e60851. doi: 10.1371/journal.pone.0060851. Print 2013.

Eight functional polymorphisms in the estrogen receptor 1 gene and endometrial cancer risk: a meta-analysis.

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1
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Liaoning, Shenyang, China.

Abstract

BACKGROUND AND OBJECTIVE:

Emerging evidence indicates that common functional polymorphisms in the estrogen receptor 1 (ESR1) gene may have an impact on an individual's susceptibility to endometrial cancer, but individually published results are inconclusive. The aim of this meta-analysis is to derive a more precise estimation of the associations between eight polymorphisms in the ESR1 gene and endometrial cancer risk.

METHODS:

A literature search of PubMed, Embase, Web of Science and China Biology Medicine (CBM) databases was conducted on publications published before November 1(st), 2012. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using the STATA 12.0 software.

RESULTS:

Thirteen case-control studies were included with a total of 7,649 endometrial cancer cases and 16,855 healthy controls. When all the eligible studies were pooled into the meta-analysis, the results indicated that PvuII (C>T) polymorphism was associated with an increased risk of endometrial cancer, especially among Caucasian populations. There were also significant associations between rs3020314 (C>T) polymorphism and an increased risk of endometrial cancer. Furthermore, rs2234670 (S/L) polymorphism may decrease the risk of endometrial cancer. However, no statistically significant associations were found in XbaI (A>G), Codon 325 (C>G), Codon 243 (C>T), VNTR (S/L) and rs2046210 (G>A) polymorphisms.

CONCLUSION:

The current meta-analysis suggests that PvuII (C>T) and rs3020314 (C>T) polymorphisms may be risk factors for endometrial cancer, especially among Caucasian populations.

PMID:
23593326
PMCID:
PMC3620469
DOI:
10.1371/journal.pone.0060851
[Indexed for MEDLINE]
Free PMC Article
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