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PLoS One. 2013 Apr 8;8(4):e60064. doi: 10.1371/journal.pone.0060064. Print 2013.

Is a persistent global bias necessary for the establishment of planar cell polarity?

Author information

1
Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom. Sabine.Fischer@physikalischebiologie.de

Abstract

Planar cell polarity (PCP)--the coordinated polarisation of a whole field of cells within the plane of a tissue-relies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local module that aligns the axis of polarisation of neighbouring cells, and a readout module that directs the correct outgrowth of PCP-regulated structures such as hairs and bristles. While much is known about the molecular components that are required for PCP, the functional details of--and interactions between--the modules remain unclear. In this work, we perform a mathematical and computational analysis of two previously proposed computational models of the local module (Amonlirdviman et al., Science, 307, 2005; Le Garrec et al., Dev. Dyn., 235, 2006). Both models can reproduce wild-type and mutant phenotypes of PCP observed in the Drosophila wing under the assumption that a tissue-wide polarity cue from the global module persists throughout the development of PCP. We demonstrate that both models can also generate tissue-level PCP when provided with only a transient initial polarity cue. However, in these models such transient cues are not sufficient to ensure robustness of the resulting cellular polarisation.

PMID:
23593163
PMCID:
PMC3620226
DOI:
10.1371/journal.pone.0060064
[Indexed for MEDLINE]
Free PMC Article

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