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Chembiochem. 2013 May 10;14(7):813-7. doi: 10.1002/cbic.201300050. Epub 2013 Apr 16.

An in vivo tagging method reveals that Ras undergoes sustained activation upon transglutaminase-mediated protein serotonylation.

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  • 1Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Section 2, Taipei 11529, Taiwan.

Abstract

Don't interrupt! Protein serotonylation has been implicated in living cells, yet its role remains poorly defined because of the lack of characterization tools. We synthesized a serotonin derivative to enable selective tagging of serotonylation and to investigate its effect on Ras; the latter displayed undisrupted interaction with Raf-1 at the Ras binding domain.

PMID:
23592595
DOI:
10.1002/cbic.201300050
[PubMed - indexed for MEDLINE]
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