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EMBO Mol Med. 2013 May;5(5):661-74. doi: 10.1002/emmm.201202382. Epub 2013 Apr 17.

Resolution of inflammation: an integrated view.

Author information

1
Institute for Cardiovascular Prevention, LMU, Munich, Germany.

Abstract

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue integrity and function. This review integrates the key molecular and cellular mechanisms of resolution. We describe how abrogation of chemokine signalling blocks continued neutrophil tissue infiltration and how apoptotic neutrophils attract monocytes and macrophages to induce their clearance. Uptake of apoptotic neutrophils by macrophages reprograms macrophages towards a resolving phenotype, a key event to restore tissue homeostasis. Finally, we highlight the therapeutic potential that derives from understanding the mechanisms of resolution.

PMID:
23592557
PMCID:
PMC3662311
DOI:
10.1002/emmm.201202382
[Indexed for MEDLINE]
Free PMC Article

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