Format

Send to

Choose Destination
Am J Perinatol. 2014 Feb;31(2):167-74. doi: 10.1055/s-0033-1343770. Epub 2013 Apr 16.

Urinary neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury in preterm infants.

Author information

1
Department of Pediatric Nephrology, Inonu University, Malatya, Turkey.
2
Department of Pediatrics, Inonu University, Malatya, Turkey.
3
Department of Neonatology, Inonu University, Malatya, Turkey.
4
Department of Pediatrics, State Hospital, Malatya, Turkey.
5
Department of Biochemistry, Inonu University, Malatya, Turkey.

Abstract

BACKGROUND:

Our aims are to determine whether the urinary neutrophil gelatinase-associated lipocalin (uNGAL) can predict acute kidney injury (AKI) development in nonseptic and nonasphyxiated but critically ill preterm infants.

METHODS:

Fifty preterm infants, gestational age (GA) between 28 and 34 weeks, were included in this case control study. Blood and urine samples were taken for blood urea nitrogen, serum creatinine, and uNGAL on postnatal (PN) days 1 and 7. uNGAL levels were measured by enzyme-linked immunoassay. Clinical and laboratory characteristics of the AKI group were compared with the non-AKI group.

RESULTS:

AKI was diagnosed in six infants during the first week. The median uNGAL levels were significantly higher in the preterm infants with AKI than those of the controls on PN days 1 and 7 (p = 0.006 and p = 0.023, respectively). Backward stepwise logistic regression analysis identified that 5-minute Apgar score and uNGAL levels were significantly associated with the development of AKI, even after controlling for GA, birth weight, gender, and 1-minute Apgar score in nonseptic and nonasphyxiated but critically ill preterm infants.

CONCLUSIONS:

uNGAL can be useful as a predictive marker of AKI in nonseptic and nonasphyxiated but critically ill preterm infants.

PMID:
23592318
DOI:
10.1055/s-0033-1343770
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Georg Thieme Verlag Stuttgart, New York
Loading ...
Support Center