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Beijing Da Xue Xue Bao. 2013 Apr 18;45(2):207-10.

[Plasma prealbumin and C-reactive protein predicts coronary artery lesions in children with Kawasaki disease].

[Article in Chinese]

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Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.



To study the changes of plasma prealbumin (PA) and C-reactive protein (CRP) in children with Kawasaki disease, and to explore the importance of integral analysis of plasma PA and CRP in predicting the severity of coronary artery lesions in Kawasaki Disease.


In a retrorespective study, 108 children with Kawasaki disease admitted in our hospital were enrolled. The statistical methods included t test, Chi-square test, and ROC curve analysis. The changes of plasma PA and CRP during the disease were studied. Also, the usefulness of comprehensive analysis of PA and CRP in predicting the severity of coronary artery lesions was also evaluated.


During the acute phase of Kawasaki disease, the plasma PA level was decreased distinctly, while the CRP level increased significantly. Among the 55 cases whose plasma PA level was <80 mg/L, setting CRP=76.5 mg/L as the cutoff value, the occurrence of coronary artery dilations for those with CRP level<76.5 mg/L was significantly higher than those with CRP level >76.5 mg/L (P<0.05).


Plasma PA and CRP changed greatly during the process of Kawasaki disease. And it may be of importance in predicting the severity of coronary artery lesions, by using integrated plasma PA and CRP.

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