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Schizophr Res. 2013 Jun;147(1):46-52. doi: 10.1016/j.schres.2013.03.022. Epub 2013 Apr 13.

Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia.

Author information

1
Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: sibylle.schwab@uk-erlangen.de.
2
Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
3
Western Australian Institute for Medical Research & Centre for Medical Research, University of Western Australia, Nedlands, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia.
4
Queensland Brain Institute, University of Queensland, St. Lucia, Australia.
5
Western Australian Institute for Medical Research & Centre for Medical Research, University of Western Australia, Nedlands, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia; Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, Claremont, Australia.

Abstract

BACKGROUND:

Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background.

METHODS:

We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR-RFLP assay for confirmation of rs1344706 genotypes.

RESULTS:

We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P=0.019, OR=1.155, 95%, CI 1.025-1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706.

CONCLUSION:

We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.

PMID:
23590871
DOI:
10.1016/j.schres.2013.03.022
[Indexed for MEDLINE]

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