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Ocul Immunol Inflamm. 2013;21(1):36-43. doi: 10.3109/09273948.2012.726393.

Detection of Chlamydia and complement factors in neovascular membranes of patients with age-related macular degeneration.

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1
Department of Ophthalmology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.

Abstract

PURPOSE:

To investigate whether Chlamydia pneumoniae and complement factors were present in surgically removed choroidal neovascular membranes (CNV) of patients with age-related macular degeneration (AMD).

METHODS:

Paraffin sections of 26 CNV were stained for C. pneumoniae or the complement factors H (CFH) and C5, whereas macrophages were identified by positive CD68 staining. Clinical characteristics have been correlated to the immunohistochemical findings.

RESULTS:

C. pneumoniae was found in 68% of the investigated membranes, and 88% of these membranes were also positive for CD68. Staining for CFH and C5 gave a positive reaction in 68 and 41% of the membranes, respectively. Patients with C5-positive membranes had significantly larger CNV mean area and were younger than patients with CFH-positive membranes at the operation time point.

CONCLUSIONS:

Correlations between clinical symptoms and complement factor C5 could be shown. The results strengthen the hypothesis of an involvement of the complement system in AMD.

PMID:
23590149
DOI:
10.3109/09273948.2012.726393
[Indexed for MEDLINE]

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