Send to

Choose Destination
See comment in PubMed Commons below
Analyst. 2013 Jun 7;138(11):3163-71. doi: 10.1039/c3an00330b.

Off-line reaction monitoring of the oxidation of alkenes in water using drop coating deposition Raman (DCDR) spectroscopy.

Author information

Stratingh Institute for Chemistry, Faculty of Mathematics and Natural Sciences, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.


The application of drop coating deposition Raman (DCDR) spectroscopy to the field of reaction progress monitoring is addressed in this contribution. Although, DCDR spectroscopy has seen recent application in the study of biological fluids, its application in other areas has not yet been explored. Here we apply the technique to the catalysed oxidation of alkenes to epoxides in aqueous solutions at concentrations <10 mM. The effect of surface characteristics, background interferences, homogeneity of distribution of analytes, drying time, as well as instrumental limits of detection and calibration are discussed. We demonstrate that reproducible spectra can be obtained routinely, with relatively little variance, with short acquisition times and samples volumes of 2-10 μl and as little as 1 μg of analyte. The utility of the technique compared with online reaction monitoring by (1)H NMR and Raman spectroscopy is demonstrated in the excellent correlation between data obtained off and on-line.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Support Center