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Blood Res. 2013 Mar;48(1):10-5. doi: 10.5045/br.2013.48.1.10. Epub 2013 Mar 25.

Role of hepcidin in the pathophysiology and diagnosis of anemia.

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1
Ematologia/Coagulazione, Laboratorio di Chimica-Clinica, Ematologia e Microbiologia, Azienda Ospedaliera S.Antonio Abate di Callarate, Varese, Italy.

Abstract

This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic role of hepcidin in different types of anemia. In addition, the usefulness of hepcidin dosage is highlighted, including the problems associated with analytical methods currently used as well as the measures of its molecular isoforms. Considering the central role of hepcidin in iron arrangement, it is reasonable to ponder its therapeutic use mainly in cases of iron overload. Further clinical trials are required before implementation.

KEYWORDS:

Anemia; Ferroportin; Hepcidin; Hepcidin agonist therapy; Hepcidin measurement

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