Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Oncol. 2013 May 20;31(15):1815-24. doi: 10.1200/JCO.2012.46.5948. Epub 2013 Apr 15.

Existing and emerging technologies for tumor genomic profiling.

Author information

1
Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 44 Binney St, Dana 1539, Boston, MA 02115, USA. laura_macconaill@dfci.harvard.edu

Abstract

Ongoing global genome characterization efforts are revolutionizing our knowledge of cancer genomics and tumor biology. In parallel, information gleaned from these studies on driver cancer gene alterations--mutations, copy number alterations, translocations, and/or chromosomal rearrangements--an be leveraged, in principle, to develop a cohesive framework for individualized cancer treatment. These possibilities have been enabled, to a large degree, by revolutionary advances in genomic technologies that facilitate systematic profiling for hallmark cancer genetic alterations at increasingly fine resolutions. Ongoing innovations in existing genomics technologies, as well as the many emerging technologies, will likely continue to advance translational cancer genomics and precision cancer medicine.

PMID:
23589546
PMCID:
PMC3808234
DOI:
10.1200/JCO.2012.46.5948
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center