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J Pediatr Hematol Oncol. 2014 Jul;36(5):337-41. doi: 10.1097/MPH.0b013e3182880de0.

Image-guided percutaneous core needle biopsy of musculoskeletal tumors in children.

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*Department of Pediatrics, Division of Pediatric Hematology/Oncology ‡Department of Medicine, Division of Hematology/Oncology §Department of Surgery, Division of Surgical Oncology Departments of †Radiology ∥Pathology ¶Orthopedic Surgery, University of California, Los Angeles, Los Angeles CA.


The use of image-guided percutaneous core needle biopsy (PCNB) to obtain tissue diagnosis of musculoskeletal lesions has become the standard of care in adult patients with a success rate of over 80%. Previous reports indicate a similar success rate in diagnosing pediatric solid tumors. In this large study, we analyzed >10 years of data in which PCNB was used for tissue diagnosis of musculoskeletal lesions in children; we evaluated the histopathologic accuracy, anesthetic requirements, and complications of these procedures. In 122 children, tissue diagnosis was successfully obtained in 82% of cases, and there were 0 complications associated with the procedure. There was a significantly higher PCNB diagnostic success rate in malignant lesions (93%). These data suggest that the use of PCNB is a safe and effective means of diagnosing musculoskeletal lesions in children.

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