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Am J Med Sci. 2013 Nov;346(5):396-401. doi: 10.1097/MAJ.0b013e31828983da.

Impact of osteoporosis and its treatment on oral health.

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Department of Periodontics and Community Dentistry (SA, RSP, HSA), College of Dentistry, King Saud University, Riyadh, Saudi Arabia; People's Dental Academy (KPK), Bhopal, India; and People's College of Dental Sciences & Research Centre (PSA), Bhopal, India.


Osteoporosis has emerged as a major health problem affecting middle-aged and older individuals. It is characterized by a reduced bone mass and strength, resulting in increased susceptibility to fractures. The disease is associated with several risk factors, and increasing evidence suggests that it may be associated with oral health conditions such as periodontal disease, reduced jaw bone density and tooth loss. Besides the effects of osteoporosis on oral health, bisphosphonate-related osteonecrosis of the jaws is a major concern to the dentist. Bisphosphonate-related osteonecrosis of the jaws is a recently described adverse effect of bisphosphonate therapy. The exact mechanisms by which these drugs cause necrosis of the jaws remain unclear, and a true cause-and-effect relationship between osteonecrosis of the jaw and bisphosphonate use has not yet been established. Hence, any form of invasive dentoalveolar treatment should be performed with caution in patients taking bisphosphonates. This review discusses current evidence on osteoporosis and its treatment implications as a risk factor in the development of various oral diseases.

[Indexed for MEDLINE]

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