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Int J Biol Macromol. 2013 Jul;58:240-4. doi: 10.1016/j.ijbiomac.2013.04.009. Epub 2013 Apr 12.

The neuroprotective activities and antioxidant activities of the polysaccharides from Saccharina japonica.

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Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.


The crude polysaccharide (W) was extracted by water from Saccharina japonica and five fractions were separated by anion-exchange chromatography. And their chemical constituents, neuroprotective activities and antioxidant activities were studied. It showed that W had the neuroprotective activity while its fractions did not. In addition, the fractions displayed higher activities on hydroxyl-radical scavenging effects and reducing power than these of W. Moreover, it was speculated that the neuroprotective activities of samples were related to the hydroxyl-radical scavenging effect and reducing power while did not relate to superoxide-radical scavenging effect. Finally, it was concluded that some fractions could be good candidate antioxidants in food chemistry owing to the high antioxidant activities and their non-toxic characteristics.

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