Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Infect Dis. 2013 Oct;17(10):e857-61. doi: 10.1016/j.ijid.2013.02.017. Epub 2013 Apr 12.

Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir.

Author information

1
School of Pharmacy, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

Abstract

OBJECTIVE:

African potato (Hypoxis obtusa) is commonly used in Sub-Saharan Africa as a complementary herbal remedy for HIV-infected patients. It is unknown whether or not co-administration of African potato alters the pharmacokinetics of protease inhibitor antiretrovirals. The objective of this study was to investigate the impact of the African potato on the steady-state pharmacokinetics of ritonavir-boosted lopinavir (LPV/r).

METHODS:

Sixteen adult volunteers were administered LPV/r 400/100 mg twice a day for 14 days, followed by concomitant administration with African potato given once daily for 7 days. Lopinavir plasma exposure as estimated by the area under the concentration-time curve over the 12-h dosing interval (AUC(0-12h), AUCτ) was determined on day 14 and again on day 21. Lopinavir in plasma was analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. Steady-state AUCτ and the maximum concentration following dose administration (C(max)) were determined using non-compartmental methods using WinNonlin Professional version 5.2.1. Statistical analyses were performed using Stata version 12.1.

RESULTS:

Co-administration of African potato was not associated with any change in lopinavir AUCτ, C(max), or C(trough).

CONCLUSIONS:

African potato when taken concomitantly with LPV/r is well-tolerated and not associated with clinically significant changes in lopinavir pharmacokinetics.

KEYWORDS:

Herbal medicines; Herb–drug interactions; Hypoxis obtusa; Pharmacokinetic interactions

PMID:
23587599
PMCID:
PMC3776002
DOI:
10.1016/j.ijid.2013.02.017
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center