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Trends Cell Biol. 2013 Jul;23(7):336-44. doi: 10.1016/j.tcb.2013.03.005. Epub 2013 Apr 12.

Coordination of organ growth: principles and outstanding questions from the world of insects.

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University of Nice-Sophia Antipolis, CNRS, and INSERM, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France.


In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.

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