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J Cardiothorac Surg. 2013 Apr 15;8:89. doi: 10.1186/1749-8090-8-89.

Aggressive adenocarcinoma of the lung consisting solely of discohesive cells.

Author information

1
Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan. y.kozu@scchr.jp

Abstract

A 60-year-old Japanese man was found to have diffuse pneumonia-like shadow in the left S10 segment on chest computed tomographic scan. Transbronchial lung biopsy yielded a pathological diagnosis of poorly differentiated adenocarcinoma; subsequently, left lower lobectomy was performed. Histopathological analysis showed that the tumor consisted solely of discohesive cells with involvement of the hilar and mediastinal lymph nodes. The immunohistochemical expression of E-cadherin and β-catenin was low, whereas that of p53 was high in the tumor cells. Here, we describe a rare lung adenocarcinoma with discohesive cells, which are considered to indicate high tumor aggressiveness.

PMID:
23587182
PMCID:
PMC3639178
DOI:
10.1186/1749-8090-8-89
[Indexed for MEDLINE]
Free PMC Article
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