Format

Send to

Choose Destination
See comment in PubMed Commons below
BMC Biol. 2013 Apr 15;11:36. doi: 10.1186/1741-7007-11-36.

LKB1 and AMPK and the cancer-metabolism link - ten years after.

Author information

1
Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK. d.g.hardie@dundee.ac.uk

Abstract

The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between AMPK and cancer. Here we briefly discuss how this discovery came about, and describe some of the insights, especially into the role of AMPK in cancer, that have followed from it.

PMID:
23587167
PMCID:
PMC3626889
DOI:
10.1186/1741-7007-11-36
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center