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Biomacromolecules. 2013 May 13;14(5):1661-8. doi: 10.1021/bm400316e. Epub 2013 Apr 26.

Biomimetic silicification of demineralized hierarchical collagenous tissues.

Author information

1
Fourth Military Medical University, Xi'an, China.
2
University of Maryland Baltimore County, Baltimore, Maryland, USA.
3
University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, USA.
4
The University of Hong Kong, Hong Kong SAR, China.
5
University of Bologna, Bologna, Italy.
6
Georgia Regents University, Augusta, Georgia, USA.
#
Contributed equally

Abstract

Unlike man-made composite materials, natural biominerals containing composites usually demonstrate different levels of sophisticated hierarchical structures which are responsible for their mechanical properties and other metabolic functions. However, the complex spatial organizations of the organic-inorganic phases are far beyond what they achieved by contemporary engineering techniques. Here, we demonstrate that carbonated apatite present in collagen matrices derived from fish scale and bovine bone may be replaced by amorphous silica, using an approach that simulates what is utilized by phylogenetically ancient glass sponges. The structural hierarchy of these collagen-based biomaterials is replicated by the infiltration and condensation of fluidic polymer-stabilized silicic acid precursors within the intrafibrillar milieu of type I collagen fibrils. This facile biomimetic silicification strategy may be used for fabricating silica-based, three-dimensional functional materials with specific morphological and hierarchical requirements.

PMID:
23586938
PMCID:
PMC3824251
DOI:
10.1021/bm400316e
[Indexed for MEDLINE]
Free PMC Article
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